Drug interactions
Desflurane + Pimozide
Severity: Moderate
Desflurane and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desflurane causes dose-dependent CNS depression and can prolong the QT interval, while pimozide also prolongs QT and is sedating. Perioperative use may cause enhanced anesthetic depth, hypotension and a higher arrhythmia risk.
What this interaction means in plain words
Desflurane and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive QT prolongation.
What to do
Inform the anesthesia team of pimozide use and obtain a preoperative ECG. Monitor ECG and electrolytes perioperatively and titrate anesthetic depth carefully.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Pimozide?
MediHelp rates the interaction as moderate. Desflurane and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desflurane causes dose-dependent CNS depression and can prolong the QT interval, while pimozide also prolongs QT and is sedating. Perioperative use may cause enhanced anesthetic depth, hypotension and a higher arrhythmia risk.
How serious is the interaction between Desflurane and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of pimozide use and obtain a preoperative ECG. Monitor ECG and electrolytes perioperatively and titrate anesthetic depth carefully.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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