Drug interactions
Desflurane + Romidepsin
Severity: Moderate
Desflurane and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause ECG changes including QT prolongation, and volatile anesthetics add to this effect. The combination may increase arrhythmia risk.
What this interaction means in plain words
Desflurane and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Correct potassium and magnesium and obtain a baseline ECG before anesthesia. Monitor ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Romidepsin?
MediHelp rates the interaction as moderate. Desflurane and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause ECG changes including QT prolongation, and volatile anesthetics add to this effect. The combination may increase arrhythmia risk.
How serious is the interaction between Desflurane and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and obtain a baseline ECG before anesthesia. Monitor ECG perioperatively.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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