Drug interactions
Desflurane + Selegiline transdermal
Severity: Moderate
Desflurane and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal selegiline inhibits monoamine oxidase and the combination with anesthesia may cause hemodynamic instability. The main concern is with sympathomimetic or opioid drugs given perioperatively rather than desflurane itself, which has no well-established direct interaction.
What this interaction means in plain words
Desflurane and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition may alter catecholamine responses and hemodynamic stability during anesthesia; direct mechanism with desflurane is not well established.
What to do
Inform the anesthesia team of MAOI use and monitor blood pressure and heart rate closely. Avoid meperidine, tramadol and indirect-acting sympathomimetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Selegiline transdermal?
MediHelp rates the interaction as moderate. Desflurane and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal selegiline inhibits monoamine oxidase and the combination with anesthesia may cause hemodynamic instability. The main concern is with sympathomimetic or opioid drugs given perioperatively rather than desflurane itself, which has no well-established direct interaction.
How serious is the interaction between Desflurane and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of MAOI use and monitor blood pressure and heart rate closely. Avoid meperidine, tramadol and indirect-acting sympathomimetics.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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