Drug interactions
Desipramine + Dimenhydrinate
Severity: Moderate
Desipramine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dimenhydrinate contains diphenhydramine, a sedating anticholinergic antihistamine, which can add to the drowsiness and anticholinergic effects of desipramine. Diphenhydramine may also weakly inhibit CYP2D6, increasing desipramine exposure.
What this interaction means in plain words
Desipramine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive CNS depression and anticholinergic effects, with possible CYP2D6 inhibition.
What to do
Avoid in older adults; otherwise monitor for sedation and anticholinergic effects and reduce doses if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Dimenhydrinate
Frequently asked questions
Can I take Desipramine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Desipramine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dimenhydrinate contains diphenhydramine, a sedating anticholinergic antihistamine, which can add to the drowsiness and anticholinergic effects of desipramine. Diphenhydramine may also weakly inhibit CYP2D6, increasing desipramine exposure.
How serious is the interaction between Desipramine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in older adults; otherwise monitor for sedation and anticholinergic effects and reduce doses if they occur.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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