Drug interactions
Desipramine + Ezogabine
Severity: Moderate
Desipramine and Ezogabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ezogabine has been associated with QT prolongation and can cause urinary retention and sedation, and desipramine adds QT and anticholinergic effects. Together they may raise the risk of arrhythmia and urinary retention.
What this interaction means in plain words
Desipramine and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Ezogabine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, sedation and anticholinergic effects.
What to do
Monitor ECG and electrolytes, and watch for urinary retention and sedation; use the lowest effective ezogabine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Ezogabine
Frequently asked questions
Can I take Desipramine with Ezogabine?
MediHelp rates the interaction as moderate. Desipramine and Ezogabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ezogabine has been associated with QT prolongation and can cause urinary retention and sedation, and desipramine adds QT and anticholinergic effects. Together they may raise the risk of arrhythmia and urinary retention.
How serious is the interaction between Desipramine and Ezogabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for urinary retention and sedation; use the lowest effective ezogabine dose.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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