Drug interactions
Desipramine + Fesoterodine
Severity: Moderate
Desipramine and Fesoterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine has antimuscarinic properties that add to those of fesoterodine, increasing the risk of dry mouth, constipation, urinary retention and confusion. The burden is greatest in older or frail patients.
What this interaction means in plain words
Desipramine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects, especially urinary retention and cognitive changes, and lower doses if they occur. Consider alternatives with lower anticholinergic activity in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fesoterodine
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Fesoterodine?
MediHelp rates the interaction as moderate. Desipramine and Fesoterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine has antimuscarinic properties that add to those of fesoterodine, increasing the risk of dry mouth, constipation, urinary retention and confusion. The burden is greatest in older or frail patients.
How serious is the interaction between Desipramine and Fesoterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, especially urinary retention and cognitive changes, and lower doses if they occur. Consider alternatives with lower anticholinergic activity in older patients.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Clozapine, Levoketoconazole. The full list is on the Fesoterodine page.
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