Drug interactions
Desipramine + Fingolimod
Severity: Major
Desipramine and Fingolimod: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod causes bradycardia and can be associated with QT prolongation, while desipramine can prolong QTc and slow conduction. Combined use may increase the risk of serious bradyarrhythmia or torsades de pointes, particularly after the first dose.
What this interaction means in plain words
Desipramine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Fingolimod belongs to Central Nervous System.
Why it happens
Additive bradycardic and QT-prolonging effects.
What to do
Perform baseline ECG and observe the first fingolimod dose with continued monitoring, and consider alternatives in patients with other QT risk factors; correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Frequently asked questions
Can I take Desipramine with Fingolimod?
MediHelp rates the interaction as major. Desipramine and Fingolimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fingolimod causes bradycardia and can be associated with QT prolongation, while desipramine can prolong QTc and slow conduction. Combined use may increase the risk of serious bradyarrhythmia or torsades de pointes, particularly after the first dose.
How serious is the interaction between Desipramine and Fingolimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform baseline ECG and observe the first fingolimod dose with continued monitoring, and consider alternatives in patients with other QT risk factors; correct electrolytes.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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