Drug interactions
Desipramine + Glipizide-metformin
Severity: Minor
Desipramine and Glipizide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may modestly enhance glucose lowering and have been linked to hypoglycemia in patients on antidiabetic drugs. They may also mask hypoglycemic symptoms through anticholinergic effects.
What this interaction means in plain words
Desipramine and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Glipizide-metformin belongs to Endocrine.
Why it happens
Tricyclics may alter insulin sensitivity and glucose regulation, though the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping desipramine and reduce the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Glipizide-metformin?
MediHelp rates the interaction as minor. Desipramine and Glipizide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may modestly enhance glucose lowering and have been linked to hypoglycemia in patients on antidiabetic drugs. They may also mask hypoglycemic symptoms through anticholinergic effects.
How serious is the interaction between Desipramine and Glipizide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping desipramine and reduce the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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