Drug interactions
Desipramine + Pazopanib
Severity: Major
Desipramine and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib is associated with QT prolongation and torsades de pointes, and desipramine can add to QT effects. Pazopanib also inhibits CYP2D6 and may raise desipramine concentrations.
What this interaction means in plain words
Desipramine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desipramine belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive QT prolongation, with pazopanib inhibition of CYP2D6 raising desipramine exposure.
What to do
Check the ECG and electrolytes at baseline and during treatment. Consider an alternative antidepressant or reduce the desipramine dose with close monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Desipramine with Pazopanib?
MediHelp rates the interaction as major. Desipramine and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib is associated with QT prolongation and torsades de pointes, and desipramine can add to QT effects. Pazopanib also inhibits CYP2D6 and may raise desipramine concentrations.
How serious is the interaction between Desipramine and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and electrolytes at baseline and during treatment. Consider an alternative antidepressant or reduce the desipramine dose with close monitoring.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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