Drug interactions
Desipramine + Salbutamol
Severity: Moderate
Desipramine and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may potentiate cardiovascular effects of beta-agonists such as tachycardia and arrhythmia. The effect is mostly of concern with high-dose or systemic salbutamol.
What this interaction means in plain words
Desipramine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Salbutamol belongs to Respiratory.
Why it happens
Tricyclic inhibition of norepinephrine reuptake enhances adrenergic cardiovascular responses.
What to do
Monitor heart rate, rhythm and blood pressure, especially in patients with cardiac disease, and use the lowest effective salbutamol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Salbutamol?
MediHelp rates the interaction as moderate. Desipramine and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants may potentiate cardiovascular effects of beta-agonists such as tachycardia and arrhythmia. The effect is mostly of concern with high-dose or systemic salbutamol.
How serious is the interaction between Desipramine and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure, especially in patients with cardiac disease, and use the lowest effective salbutamol dose.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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