Drug interactions
Desipramine + Selpercatinib
Severity: Moderate
Desipramine and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selpercatinib can prolong the QT interval, and desipramine may also affect repolarization, so the combination may raise the risk of torsades de pointes. Additionally, selpercatinib is a weak CYP2D6 inhibitor and could modestly increase desipramine exposure.
What this interaction means in plain words
Desipramine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible weak CYP2D6 inhibition by selpercatinib increasing desipramine levels.
What to do
Monitor ECG and electrolytes at baseline and periodically, correcting hypokalemia and hypomagnesemia. Consider an alternative antidepressant or lower desipramine dose if QTc lengthens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Desipramine with Selpercatinib?
MediHelp rates the interaction as moderate. Desipramine and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selpercatinib can prolong the QT interval, and desipramine may also affect repolarization, so the combination may raise the risk of torsades de pointes. Additionally, selpercatinib is a weak CYP2D6 inhibitor and could modestly increase desipramine exposure.
How serious is the interaction between Desipramine and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, correcting hypokalemia and hypomagnesemia. Consider an alternative antidepressant or lower desipramine dose if QTc lengthens.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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