Drug interactions
Desipramine + Sorafenib
Severity: Moderate
Desipramine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease. The risk is additive rather than dramatic at usual doses.
What this interaction means in plain words
Desipramine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through cardiac repolarization effects.
What to do
Obtain a baseline ECG and repeat it after starting the combination, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Desipramine with Sorafenib?
MediHelp rates the interaction as moderate. Desipramine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly with electrolyte disturbances or heart disease. The risk is additive rather than dramatic at usual doses.
How serious is the interaction between Desipramine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat it after starting the combination, and correct potassium and magnesium abnormalities. Consider an alternative antidepressant if the QTc becomes markedly prolonged.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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