Drug interactions
Desipramine + Suvorexant
Severity: Moderate
Desipramine and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant causes somnolence and impaired next-day alertness, and desipramine is also sedating. Together they may increase drowsiness and impair psychomotor performance and driving.
What this interaction means in plain words
Desipramine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and the sedative properties of desipramine.
What to do
Use the lowest effective suvorexant dose and counsel patients about next-day impairment and driving. Reduce the dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desipramine and Suvorexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Desipramine with Suvorexant?
MediHelp rates the interaction as moderate. Desipramine and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant causes somnolence and impaired next-day alertness, and desipramine is also sedating. Together they may increase drowsiness and impair psychomotor performance and driving.
How serious is the interaction between Desipramine and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective suvorexant dose and counsel patients about next-day impairment and driving. Reduce the dose if excessive sedation occurs.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
