Drug interactions
Desipramine + Vandetanib
Severity: Contraindicated
Desipramine and Vandetanib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib causes marked QT prolongation, and desipramine adds to this effect, increasing the risk of torsades de pointes and sudden death. Vandetanib labeling advises avoiding other QT-prolonging drugs.
What this interaction means in plain words
Desipramine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Desipramine belongs to Central Nervous System; Vandetanib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Avoid the combination and choose a non-QT-prolonging antidepressant. If the antidepressant is essential, obtain frequent ECGs and keep potassium and magnesium normal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Desipramine with Vandetanib?
MediHelp rates the interaction as contraindicated. Desipramine and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib causes marked QT prolongation, and desipramine adds to this effect, increasing the risk of torsades de pointes and sudden death. Vandetanib labeling advises avoiding other QT-prolonging drugs.
How serious is the interaction between Desipramine and Vandetanib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose a non-QT-prolonging antidepressant. If the antidepressant is essential, obtain frequent ECGs and keep potassium and magnesium normal.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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