Drug interactions
Desloratadine + Erythromycin base
Severity: Minor
Desloratadine and Erythromycin base: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin modestly increases desloratadine plasma concentrations in pharmacokinetic studies. No meaningful changes in QT interval or other clinical effects were seen, so the interaction is of limited significance.
What this interaction means in plain words
Desloratadine and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of P-glycoprotein and metabolic clearance of desloratadine by erythromycin.
What to do
No dose adjustment is needed. Monitor for increased antihistamine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Frequently asked questions
Can I take Desloratadine with Erythromycin base?
MediHelp rates the interaction as minor. Desloratadine and Erythromycin base have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin modestly increases desloratadine plasma concentrations in pharmacokinetic studies. No meaningful changes in QT interval or other clinical effects were seen, so the interaction is of limited significance.
How serious is the interaction between Desloratadine and Erythromycin base?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for increased antihistamine adverse effects.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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