Drug interactions
Berotralstat + Desloratadine
Severity: Minor
Berotralstat and Desloratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as desloratadine. Because desloratadine has a wide therapeutic margin, the clinical impact is likely small.
What this interaction means in plain words
Berotralstat and Desloratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Desloratadine belongs to Respiratory.
Why it happens
Inhibition of P-glycoprotein efflux by berotralstat, increasing desloratadine absorption.
What to do
No routine dose change is needed; monitor for antihistamine adverse effects such as drowsiness or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Bosutinib + Desloratadine Minor
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Desloratadine?
MediHelp rates the interaction as minor. Berotralstat and Desloratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and may raise concentrations of P-gp substrates such as desloratadine. Because desloratadine has a wide therapeutic margin, the clinical impact is likely small.
How serious is the interaction between Berotralstat and Desloratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for antihistamine adverse effects such as drowsiness or palpitations.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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