Drug interactions
Desloratadine + Tranylcypromine
Severity: Moderate
Desloratadine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may intensify and prolong the anticholinergic and sedative effects of antihistamines. Desloratadine is non-sedating at usual doses, so the effect is generally mild.
What this interaction means in plain words
Desloratadine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desloratadine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression, with MAO inhibition possibly potentiating antihistamine anticholinergic effects.
What to do
Monitor for drowsiness and anticholinergic symptoms such as dry mouth or urinary retention. Advise caution with driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
- Bosutinib + Desloratadine Minor
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Desloratadine with Tranylcypromine?
MediHelp rates the interaction as moderate. Desloratadine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may intensify and prolong the anticholinergic and sedative effects of antihistamines. Desloratadine is non-sedating at usual doses, so the effect is generally mild.
How serious is the interaction between Desloratadine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and anticholinergic symptoms such as dry mouth or urinary retention. Advise caution with driving until the response is known.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Zuranolone. The full list is on the Desloratadine page.
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