Drug interactions
Desloratadine + Zuranolone
Severity: Moderate
Desloratadine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes significant somnolence and impaired driving ability. Desloratadine is minimally sedating, so any additional effect is likely small, but additive CNS effects are possible.
What this interaction means in plain words
Desloratadine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desloratadine belongs to Respiratory; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression, predominantly from zuranolone's GABA-A modulation.
What to do
Counsel on sedation and driving impairment. Reduce the zuranolone dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
- Bosutinib + Desloratadine Minor
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Desloratadine with Zuranolone?
MediHelp rates the interaction as moderate. Desloratadine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes significant somnolence and impaired driving ability. Desloratadine is minimally sedating, so any additional effect is likely small, but additive CNS effects are possible.
How serious is the interaction between Desloratadine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on sedation and driving impairment. Reduce the zuranolone dose if excessive sedation occurs.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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