Drug interactions
Desloratadine + Esketamine intranasal
Severity: Minor
Desloratadine and Esketamine intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes sedation and dissociation, and desloratadine may rarely add to drowsiness. The extra effect is expected to be small.
What this interaction means in plain words
Desloratadine and Esketamine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects.
What to do
Observe for sedation during the post-dose monitoring period and advise against driving until the next day, as required with esketamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Frequently asked questions
Can I take Desloratadine with Esketamine intranasal?
MediHelp rates the interaction as minor. Desloratadine and Esketamine intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Esketamine causes sedation and dissociation, and desloratadine may rarely add to drowsiness. The extra effect is expected to be small.
How serious is the interaction between Desloratadine and Esketamine intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for sedation during the post-dose monitoring period and advise against driving until the next day, as required with esketamine.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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