Drug interactions
Desloratadine + Esketamine
Severity: Minor
Desloratadine and Esketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desloratadine is a non-sedating antihistamine that rarely causes drowsiness at usual doses. Any added sedation with esketamine is likely small.
What this interaction means in plain words
Desloratadine and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desloratadine belongs to Respiratory; Esketamine belongs to Central Nervous System.
Why it happens
Possible slight additive CNS depression; desloratadine has minimal central penetration.
What to do
No change is usually needed. Observe patients as routine for sedation after esketamine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Frequently asked questions
Can I take Desloratadine with Esketamine?
MediHelp rates the interaction as minor. Desloratadine and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desloratadine is a non-sedating antihistamine that rarely causes drowsiness at usual doses. Any added sedation with esketamine is likely small.
How serious is the interaction between Desloratadine and Esketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is usually needed. Observe patients as routine for sedation after esketamine.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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