Drug interactions
Desogestrel + Exenatide
Severity: Minor
Desogestrel and Exenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide slows gastric emptying and can reduce the rate of absorption of oral drugs, which could lower contraceptive peak levels. Hormonal contraceptives may also slightly impair glucose tolerance. Clinical significance with desogestrel is probably small.
What this interaction means in plain words
Desogestrel and Exenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel belongs to Endocrine; Exenatide belongs to Endocrine.
Why it happens
Delayed gastric emptying by exenatide alters oral absorption; progestogens may have a minor effect on glucose tolerance.
What to do
Take the oral contraceptive at least one hour before exenatide. Monitor glucose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Exenatide
- Chlorpropamide + Exenatide Major
- Asenapine + Exenatide Moderate
- Betamethasone + Exenatide Moderate
- Chlorothiazide + Exenatide Moderate
- Clozapine + Exenatide Moderate
- Cortisone + Exenatide Moderate
Other interactions of Desogestrel
- Carbamazepine + Desogestrel Major
- Berotralstat + Desogestrel Moderate
- Desogestrel + Lamotrigine Moderate
- Desogestrel + Mifepristone Moderate
- Desogestrel + Warfarin Moderate
- Alogliptin-metformin + Desogestrel Minor
Frequently asked questions
Can I take Desogestrel with Exenatide?
MediHelp rates the interaction as minor. Desogestrel and Exenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Exenatide slows gastric emptying and can reduce the rate of absorption of oral drugs, which could lower contraceptive peak levels. Hormonal contraceptives may also slightly impair glucose tolerance. Clinical significance with desogestrel is probably small.
How serious is the interaction between Desogestrel and Exenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the oral contraceptive at least one hour before exenatide. Monitor glucose.
What other medicines interact with Exenatide?
MediHelp also lists interactions of Exenatide with, for example, Chlorpropamide, Asenapine, Betamethasone. The full list is on the Exenatide page.
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