Drug interactions
Desogestrel + Mifepristone
Severity: Moderate
Desogestrel and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone is a progesterone receptor antagonist and may blunt the effect of progestins used for contraception. This could reduce contraceptive reliability.
What this interaction means in plain words
Desogestrel and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism at the progesterone receptor.
What to do
Use a non-hormonal backup contraceptive method during mifepristone treatment and for the period advised in labeling afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Desogestrel
- Carbamazepine + Desogestrel Major
- Berotralstat + Desogestrel Moderate
- Desogestrel + Lamotrigine Moderate
- Desogestrel + Warfarin Moderate
- Alogliptin-metformin + Desogestrel Minor
- Canagliflozin-metformin + Desogestrel Minor
Frequently asked questions
Can I take Desogestrel with Mifepristone?
MediHelp rates the interaction as moderate. Desogestrel and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone is a progesterone receptor antagonist and may blunt the effect of progestins used for contraception. This could reduce contraceptive reliability.
How serious is the interaction between Desogestrel and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal backup contraceptive method during mifepristone treatment and for the period advised in labeling afterward.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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