Drug interactions
Desogestrel + Warfarin
Severity: Moderate
Desogestrel and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hormonal contraceptives can alter coagulation factors and have occasionally been associated with changes in INR in warfarin users. Progestin-only agents have limited effect, and estrogen-containing products also carry thrombotic risk.
What this interaction means in plain words
Desogestrel and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel belongs to Endocrine; Warfarin belongs to Cardiovascular.
Why it happens
Hormonal effects on clotting factor synthesis; mechanism incompletely characterized.
What to do
Check INR after starting or stopping desogestrel and adjust warfarin as needed. Avoid estrogen-containing preparations in patients needing anticoagulation where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Desogestrel
- Carbamazepine + Desogestrel Major
- Berotralstat + Desogestrel Moderate
- Desogestrel + Lamotrigine Moderate
- Desogestrel + Mifepristone Moderate
- Alogliptin-metformin + Desogestrel Minor
- Canagliflozin-metformin + Desogestrel Minor
Frequently asked questions
Can I take Desogestrel with Warfarin?
MediHelp rates the interaction as moderate. Desogestrel and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hormonal contraceptives can alter coagulation factors and have occasionally been associated with changes in INR in warfarin users. Progestin-only agents have limited effect, and estrogen-containing products also carry thrombotic risk.
How serious is the interaction between Desogestrel and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR after starting or stopping desogestrel and adjust warfarin as needed. Avoid estrogen-containing preparations in patients needing anticoagulation where possible.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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