Drug interactions
Berotralstat + Desogestrel
Severity: Moderate
Berotralstat and Desogestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat can increase exposure to etonogestrel, the active metabolite of desogestrel. This may increase progestogenic adverse effects.
What this interaction means in plain words
Berotralstat and Desogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Desogestrel belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 or transporters by berotralstat reduces clearance of etonogestrel.
What to do
Weigh benefits and risks and watch for progestogen-related adverse effects such as bleeding changes and mood effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Other interactions of Desogestrel
- Carbamazepine + Desogestrel Major
- Desogestrel + Lamotrigine Moderate
- Desogestrel + Mifepristone Moderate
- Desogestrel + Warfarin Moderate
- Alogliptin-metformin + Desogestrel Minor
- Canagliflozin-metformin + Desogestrel Minor
Frequently asked questions
Can I take Berotralstat with Desogestrel?
MediHelp rates the interaction as moderate. Berotralstat and Desogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat can increase exposure to etonogestrel, the active metabolite of desogestrel. This may increase progestogenic adverse effects.
How serious is the interaction between Berotralstat and Desogestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Weigh benefits and risks and watch for progestogen-related adverse effects such as bleeding changes and mood effects.
What other medicines interact with Berotralstat?
MediHelp also lists interactions of Berotralstat with, for example, Ergotamine, Nilotinib, Pimozide. The full list is on the Berotralstat page.
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