Drug interactions
Desogestrel + Metformin-sitagliptin
Severity: Minor
Desogestrel and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hormonal contraceptives containing desogestrel may slightly impair glucose tolerance. The effect on glycemic control is usually small.
What this interaction means in plain words
Desogestrel and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel belongs to Endocrine; Metformin-sitagliptin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through mild progestogen and estrogen effects on insulin sensitivity.
What to do
Monitor blood glucose after starting the contraceptive. Adjust antidiabetic therapy only if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desogestrel and Metformin-sitagliptin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-sitagliptin
Other interactions of Desogestrel
- Carbamazepine + Desogestrel Major
- Berotralstat + Desogestrel Moderate
- Desogestrel + Lamotrigine Moderate
- Desogestrel + Mifepristone Moderate
- Desogestrel + Warfarin Moderate
- Alogliptin-metformin + Desogestrel Minor
Frequently asked questions
Can I take Desogestrel with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Desogestrel and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hormonal contraceptives containing desogestrel may slightly impair glucose tolerance. The effect on glycemic control is usually small.
How serious is the interaction between Desogestrel and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting the contraceptive. Adjust antidiabetic therapy only if control worsens.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
