Drug interactions
Desogestrel-ethinyl estradiol + Eltrombopag
Severity: Minor
Desogestrel-ethinyl estradiol and Eltrombopag: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag is metabolized in part by CYP1A2, which ethinyl estradiol inhibits weakly. Exposure might rise slightly, but this is unlikely to be clinically important. Eltrombopag also carries hepatotoxicity and thrombosis risks, so estrogen-related clotting risk is worth considering.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Eltrombopag belongs to Miscellaneous.
Why it happens
Weak CYP1A2 inhibition by ethinyl estradiol may slightly reduce eltrombopag metabolism.
What to do
No dose adjustment is required; monitor liver tests and platelet counts as per eltrombopag labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Eltrombopag?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Eltrombopag have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag is metabolized in part by CYP1A2, which ethinyl estradiol inhibits weakly. Exposure might rise slightly, but this is unlikely to be clinically important. Eltrombopag also carries hepatotoxicity and thrombosis risks, so estrogen-related clotting risk is worth considering.
How serious is the interaction between Desogestrel-ethinyl estradiol and Eltrombopag?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor liver tests and platelet counts as per eltrombopag labeling.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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