Drug interactions
Desogestrel-ethinyl estradiol + Lapatinib
Severity: Minor
Desogestrel-ethinyl estradiol and Lapatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a CYP3A4 substrate and ethinyl estradiol is only a weak CYP3A4 inhibitor, so a clinically meaningful rise in lapatinib is unlikely. Lapatinib itself is also not a recognized contraceptive reducer, though pregnancy must be avoided during therapy.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Lapatinib belongs to Oncology.
Why it happens
Ethinyl estradiol may weakly inhibit CYP3A4, but the effect on lapatinib is not well established.
What to do
No specific action is needed beyond routine monitoring of lapatinib adverse effects such as diarrhea and hepatotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Lapatinib?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Lapatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lapatinib is a CYP3A4 substrate and ethinyl estradiol is only a weak CYP3A4 inhibitor, so a clinically meaningful rise in lapatinib is unlikely. Lapatinib itself is also not a recognized contraceptive reducer, though pregnancy must be avoided during therapy.
How serious is the interaction between Desogestrel-ethinyl estradiol and Lapatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of lapatinib adverse effects such as diarrhea and hepatotoxicity.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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