Drug interactions
Desogestrel-ethinyl estradiol + Leniolisib
Severity: Minor
Desogestrel-ethinyl estradiol and Leniolisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP and may modestly raise exposure to BCRP substrates. The clinical impact on a combined oral contraceptive is expected to be small.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Leniolisib belongs to Miscellaneous.
Why it happens
BCRP inhibition by leniolisib may reduce efflux of the contraceptive steroids and slightly raise exposure.
What to do
No routine change is needed. Be aware of possible estrogen-related adverse effects and review if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Leniolisib?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Leniolisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leniolisib inhibits BCRP and may modestly raise exposure to BCRP substrates. The clinical impact on a combined oral contraceptive is expected to be small.
How serious is the interaction between Desogestrel-ethinyl estradiol and Leniolisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Be aware of possible estrogen-related adverse effects and review if symptoms occur.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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