Drug interactions
Desogestrel-ethinyl estradiol + Nicardipine
Severity: Minor
Desogestrel-ethinyl estradiol and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol might slightly raise nicardipine exposure, which could increase hypotension, flushing or edema. The effect is expected to be small.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Nicardipine belongs to Cardiovascular.
Why it happens
Ethinyl estradiol may weakly inhibit CYP3A4-mediated metabolism of nicardipine.
What to do
Monitor blood pressure and heart rate when starting the contraceptive and adjust the nicardipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Nicardipine
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Nicardipine?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol might slightly raise nicardipine exposure, which could increase hypotension, flushing or edema. The effect is expected to be small.
How serious is the interaction between Desogestrel-ethinyl estradiol and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting the contraceptive and adjust the nicardipine dose if hypotension occurs.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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