Drug interactions
Desogestrel-ethinyl estradiol + Ramelteon
Severity: Minor
Desogestrel-ethinyl estradiol and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is mainly metabolized by CYP1A2, which ethinyl estradiol inhibits weakly. Ramelteon exposure may rise, causing more drowsiness or dizziness.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desogestrel-ethinyl estradiol belongs to Endocrine; Ramelteon belongs to Central Nervous System.
Why it happens
Weak CYP1A2 inhibition by ethinyl estradiol reduces ramelteon clearance.
What to do
Monitor for next-day sedation and dizziness; reduce the ramelteon dose if effects are troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Ramelteon?
MediHelp rates the interaction as minor. Desogestrel-ethinyl estradiol and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is mainly metabolized by CYP1A2, which ethinyl estradiol inhibits weakly. Ramelteon exposure may rise, causing more drowsiness or dizziness.
How serious is the interaction between Desogestrel-ethinyl estradiol and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for next-day sedation and dizziness; reduce the ramelteon dose if effects are troublesome.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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