Drug interactions
Desogestrel-ethinyl estradiol + Sparsentan
Severity: Moderate
Desogestrel-ethinyl estradiol and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan can induce CYP enzymes and may reduce exposure to the hormones in combined oral contraceptives. Sparsentan is also associated with embryo-fetal toxicity and is available only through a restricted program, so reliable contraception is important. Reduced contraceptive efficacy would be undesirable.
What this interaction means in plain words
Desogestrel-ethinyl estradiol and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desogestrel-ethinyl estradiol belongs to Endocrine; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan weakly induces CYP enzymes (including CYP2C19 and CYP3A4), which may increase the clearance of the contraceptive hormones.
What to do
Confirm the patient is following the sparsentan pregnancy-prevention requirements and consider adding a non-hormonal barrier method. Monitor for breakthrough bleeding and perform pregnancy tests as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Aminocaproic acid + Desogestrel-ethinyl estradiol Major
- Amobarbital + Desogestrel-ethinyl estradiol Major
- Anastrozole + Desogestrel-ethinyl estradiol Major
- Apalutamide + Desogestrel-ethinyl estradiol Major
- Atazanavir + Desogestrel-ethinyl estradiol Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Desogestrel-ethinyl estradiol with Sparsentan?
MediHelp rates the interaction as moderate. Desogestrel-ethinyl estradiol and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan can induce CYP enzymes and may reduce exposure to the hormones in combined oral contraceptives. Sparsentan is also associated with embryo-fetal toxicity and is available only through a restricted program, so reliable contraception is important. Reduced contraceptive efficacy would be undesirable.
How serious is the interaction between Desogestrel-ethinyl estradiol and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Confirm the patient is following the sparsentan pregnancy-prevention requirements and consider adding a non-hormonal barrier method. Monitor for breakthrough bleeding and perform pregnancy tests as required.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
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