Drug interactions
Desvenlafaxine + Flecainide
Severity: Moderate
Desvenlafaxine and Flecainide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP2D6 inhibitor, and at higher doses it may modestly increase flecainide exposure. Because flecainide has a narrow therapeutic index, even small increases can matter.
What this interaction means in plain words
Desvenlafaxine and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Flecainide belongs to Cardiovascular.
Why it happens
Desvenlafaxine inhibits CYP2D6 metabolism of flecainide.
What to do
Monitor ECG and flecainide levels, especially with higher desvenlafaxine doses. Reduce the flecainide dose if conduction intervals lengthen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flecainide
- Flecainide + Nirmatrelvir Contraindicated
- Flecainide + Nirmatrelvir / ritonavir Contraindicated
- Flecainide + Pimozide Contraindicated
- Flecainide + Ritonavir Contraindicated
- Flecainide + Thioridazine Contraindicated
- Flecainide + Tipranavir Contraindicated
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Flecainide?
MediHelp rates the interaction as moderate. Desvenlafaxine and Flecainide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desvenlafaxine is a weak CYP2D6 inhibitor, and at higher doses it may modestly increase flecainide exposure. Because flecainide has a narrow therapeutic index, even small increases can matter.
How serious is the interaction between Desvenlafaxine and Flecainide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and flecainide levels, especially with higher desvenlafaxine doses. Reduce the flecainide dose if conduction intervals lengthen.
What other medicines interact with Flecainide?
MediHelp also lists interactions of Flecainide with, for example, Nirmatrelvir, Nirmatrelvir / ritonavir, Pimozide. The full list is on the Flecainide page.
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