Drug interactions
Desvenlafaxine + Lemborexant
Severity: Minor
Desvenlafaxine and Lemborexant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant is a CYP3A4 substrate and weak CYP3A4 inhibitors can raise its exposure, but desvenlafaxine has little CYP3A4 inhibitory effect. Lemborexant also causes somnolence which could add to other CNS-active drugs.
What this interaction means in plain words
Desvenlafaxine and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Possible weak CYP3A4 inhibition plus additive CNS effects.
What to do
Start with the lowest lemborexant dose and monitor for next-day somnolence and impaired driving. Adjust dose according to tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Desvenlafaxine and Lemborexant, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Desvenlafaxine with Lemborexant?
MediHelp rates the interaction as minor. Desvenlafaxine and Lemborexant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lemborexant is a CYP3A4 substrate and weak CYP3A4 inhibitors can raise its exposure, but desvenlafaxine has little CYP3A4 inhibitory effect. Lemborexant also causes somnolence which could add to other CNS-active drugs.
How serious is the interaction between Desvenlafaxine and Lemborexant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest lemborexant dose and monitor for next-day somnolence and impaired driving. Adjust dose according to tolerability.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
