Drug interactions
Desvenlafaxine + Maprotiline
Severity: Moderate
Desvenlafaxine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline and desvenlafaxine both enhance noradrenergic and serotonergic neurotransmission, which can cause serotonin toxicity in susceptible patients. Maprotiline also lowers the seizure threshold and desvenlafaxine can raise blood pressure.
What this interaction means in plain words
Desvenlafaxine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive monoamine reuptake inhibition producing pharmacodynamic serotonergic and noradrenergic effects.
What to do
Use the lowest effective doses and start any addition slowly. Monitor for agitation, tremor, hyperreflexia, sweating and fever, and check blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Maprotiline?
MediHelp rates the interaction as moderate. Desvenlafaxine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline and desvenlafaxine both enhance noradrenergic and serotonergic neurotransmission, which can cause serotonin toxicity in susceptible patients. Maprotiline also lowers the seizure threshold and desvenlafaxine can raise blood pressure.
How serious is the interaction between Desvenlafaxine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and start any addition slowly. Monitor for agitation, tremor, hyperreflexia, sweating and fever, and check blood pressure.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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