Drug interactions
Desvenlafaxine + Oliceridine
Severity: Moderate
Desvenlafaxine and Oliceridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids with serotonergic activity have been linked to serotonin syndrome with SNRIs, although oliceridine has little direct serotonergic activity. The more relevant concern is additive CNS and respiratory depression with other agents.
What this interaction means in plain words
Desvenlafaxine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Possible additive serotonergic effects and CNS depression.
What to do
Monitor for features of serotonin syndrome and for sedation and respiratory depression, particularly after dose increases. Use the lowest effective oliceridine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Desvenlafaxine with Oliceridine?
MediHelp rates the interaction as moderate. Desvenlafaxine and Oliceridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids with serotonergic activity have been linked to serotonin syndrome with SNRIs, although oliceridine has little direct serotonergic activity. The more relevant concern is additive CNS and respiratory depression with other agents.
How serious is the interaction between Desvenlafaxine and Oliceridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for features of serotonin syndrome and for sedation and respiratory depression, particularly after dose increases. Use the lowest effective oliceridine dose.
What other medicines interact with Desvenlafaxine?
MediHelp also lists interactions of Desvenlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Desvenlafaxine page.
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