Drug interactions
Desvenlafaxine + Oxymorphone
Severity: Minor
Desvenlafaxine and Oxymorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine is a weak CYP2D6 inhibitor, but oxymorphone is not mainly cleared by CYP2D6, so a meaningful pharmacokinetic effect is unlikely. A pharmacodynamic concern remains because serotonergic agents combined with opioids can rarely cause serotonin syndrome, and CNS depression may be additive.
What this interaction means in plain words
Desvenlafaxine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desvenlafaxine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Weak CYP2D6 inhibition of doubtful relevance, plus a possible additive serotonergic and CNS effect.
What to do
No dose change is usually needed; watch for sedation and for signs of serotonin syndrome, especially after dose increases.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Oxymorphone?
MediHelp rates the interaction as minor. Desvenlafaxine and Oxymorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Desvenlafaxine is a weak CYP2D6 inhibitor, but oxymorphone is not mainly cleared by CYP2D6, so a meaningful pharmacokinetic effect is unlikely. A pharmacodynamic concern remains because serotonergic agents combined with opioids can rarely cause serotonin syndrome, and CNS depression may be additive.
How serious is the interaction between Desvenlafaxine and Oxymorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for sedation and for signs of serotonin syndrome, especially after dose increases.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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