Drug interactions
Desvenlafaxine + Warfarin
Severity: Moderate
Desvenlafaxine and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desvenlafaxine inhibits serotonin reuptake into platelets, which can impair hemostasis and increase bleeding risk in warfarin users. The risk is mainly of GI and mucosal bleeding.
What this interaction means in plain words
Desvenlafaxine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desvenlafaxine belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Pharmacodynamic: SNRI-related platelet dysfunction adds to vitamin K antagonism.
What to do
Monitor for bleeding and check INR after starting or stopping desvenlafaxine. Consider gastroprotection in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Desvenlafaxine with Warfarin?
MediHelp rates the interaction as moderate. Desvenlafaxine and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desvenlafaxine inhibits serotonin reuptake into platelets, which can impair hemostasis and increase bleeding risk in warfarin users. The risk is mainly of GI and mucosal bleeding.
How serious is the interaction between Desvenlafaxine and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and check INR after starting or stopping desvenlafaxine. Consider gastroprotection in high-risk patients.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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