Drug interactions
Deutetrabenazine + Diazepam
Severity: Moderate
Deutetrabenazine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine can cause somnolence and sedation, which adds to the CNS depressant effect of diazepam. Impaired alertness and falls are the main concerns.
What this interaction means in plain words
Deutetrabenazine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression through different pharmacodynamic pathways.
What to do
Monitor for drowsiness and advise caution with driving. Reduce doses if sedation becomes troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diazepam
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Diazepam?
MediHelp rates the interaction as moderate. Deutetrabenazine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine can cause somnolence and sedation, which adds to the CNS depressant effect of diazepam. Impaired alertness and falls are the main concerns.
How serious is the interaction between Deutetrabenazine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and advise caution with driving. Reduce doses if sedation becomes troublesome.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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