Drug interactions
Deutetrabenazine + Dimenhydrinate
Severity: Moderate
Deutetrabenazine and Dimenhydrinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine commonly causes somnolence, and a sedating antihistamine can worsen drowsiness and impair alertness. Additive effects on concentration and coordination are possible.
What this interaction means in plain words
Deutetrabenazine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Dimenhydrinate belongs to Respiratory.
Why it happens
Additive CNS depression.
What to do
Monitor for excess sedation, and counsel patients about driving and machinery. Lower the dose of one agent if drowsiness is problematic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dimenhydrinate
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Dimenhydrinate?
MediHelp rates the interaction as moderate. Deutetrabenazine and Dimenhydrinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine commonly causes somnolence, and a sedating antihistamine can worsen drowsiness and impair alertness. Additive effects on concentration and coordination are possible.
How serious is the interaction between Deutetrabenazine and Dimenhydrinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, and counsel patients about driving and machinery. Lower the dose of one agent if drowsiness is problematic.
What other medicines interact with Dimenhydrinate?
MediHelp also lists interactions of Dimenhydrinate with, for example, Belladonna and opium, Brexanolone, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Dimenhydrinate page.
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