Drug interactions
Deutetrabenazine + Erythromycin
Severity: Moderate
Deutetrabenazine and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin prolongs the QT interval, and deutetrabenazine can contribute modestly to QT effects, mainly at higher exposures. The combination raises arrhythmia risk, especially with bradycardia, electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Deutetrabenazine and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Erythromycin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation, mainly from erythromycin hERG blockade with a small contribution from deutetrabenazine metabolites.
What to do
Obtain a baseline ECG and correct potassium and magnesium before and during combined use in patients with risk factors. Consider a non-QT-prolonging antibiotic if available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Erythromycin?
MediHelp rates the interaction as moderate. Deutetrabenazine and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin prolongs the QT interval, and deutetrabenazine can contribute modestly to QT effects, mainly at higher exposures. The combination raises arrhythmia risk, especially with bradycardia, electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Deutetrabenazine and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before and during combined use in patients with risk factors. Consider a non-QT-prolonging antibiotic if available.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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