Drug interactions
Deutetrabenazine + Fingolimod
Severity: Moderate
Deutetrabenazine and Fingolimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fingolimod may cause bradycardia and QT prolongation, and deutetrabenazine can modestly prolong QT, mainly at higher exposures. Together they may increase torsades risk in patients with other risk factors.
What this interaction means in plain words
Deutetrabenazine and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Fingolimod belongs to Central Nervous System.
Why it happens
Possible additive QT prolongation with fingolimod-induced bradycardia.
What to do
Check baseline ECG and electrolytes before combining. Monitor ECG during fingolimod initiation and correct hypokalemia and hypomagnesemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Fingolimod?
MediHelp rates the interaction as moderate. Deutetrabenazine and Fingolimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fingolimod may cause bradycardia and QT prolongation, and deutetrabenazine can modestly prolong QT, mainly at higher exposures. Together they may increase torsades risk in patients with other risk factors.
How serious is the interaction between Deutetrabenazine and Fingolimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes before combining. Monitor ECG during fingolimod initiation and correct hypokalemia and hypomagnesemia.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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