Drug interactions
Deutetrabenazine + Fluticasone-salmeterol
Severity: Moderate
Deutetrabenazine and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol can prolong the QT interval and cause hypokalemia, especially at high doses. Deutetrabenazine has a small QT effect that may become relevant in the presence of other risk factors. Combined use may modestly increase proarrhythmic risk in predisposed patients.
What this interaction means in plain words
Deutetrabenazine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive QT prolongation, with salmeterol-induced hypokalemia as an additional contributor.
What to do
Obtain a baseline ECG and correct potassium and magnesium abnormalities in patients with QT risk factors. Avoid exceeding recommended salmeterol doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Deutetrabenazine and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol can prolong the QT interval and cause hypokalemia, especially at high doses. Deutetrabenazine has a small QT effect that may become relevant in the presence of other risk factors. Combined use may modestly increase proarrhythmic risk in predisposed patients.
How serious is the interaction between Deutetrabenazine and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium abnormalities in patients with QT risk factors. Avoid exceeding recommended salmeterol doses.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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