Drug interactions
Deutetrabenazine + Imipramine
Severity: Moderate
Deutetrabenazine and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation, and each can contribute to QT prolongation. Together they may increase somnolence and the risk of ventricular arrhythmias, especially with electrolyte disturbances or bradycardia. Imipramine may also increase deutetrabenazine metabolite exposure if it inhibits CYP2D6.
What this interaction means in plain words
Deutetrabenazine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Imipramine belongs to Central Nervous System.
Why it happens
Additive CNS depression and QT prolongation.
What to do
Check an ECG and correct potassium and magnesium before and during combined use. Monitor for sedation and depression, and adjust doses if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Imipramine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation, and each can contribute to QT prolongation. Together they may increase somnolence and the risk of ventricular arrhythmias, especially with electrolyte disturbances or bradycardia. Imipramine may also increase deutetrabenazine metabolite exposure if it inhibits CYP2D6.
How serious is the interaction between Deutetrabenazine and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG and correct potassium and magnesium before and during combined use. Monitor for sedation and depression, and adjust doses if needed.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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