Drug interactions
Deutetrabenazine + Lorazepam
Severity: Moderate
Deutetrabenazine and Lorazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine can cause somnolence and depression, and lorazepam may add to sedation. Impaired alertness may affect daily activities.
What this interaction means in plain words
Deutetrabenazine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Lorazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and central monoamine depletion.
What to do
Monitor for excessive sedation and mood changes and advise caution with driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lorazepam
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Lorazepam?
MediHelp rates the interaction as moderate. Deutetrabenazine and Lorazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine can cause somnolence and depression, and lorazepam may add to sedation. Impaired alertness may affect daily activities.
How serious is the interaction between Deutetrabenazine and Lorazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and mood changes and advise caution with driving until the response is known.
What other medicines interact with Lorazepam?
MediHelp also lists interactions of Lorazepam with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Lorazepam page.
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