Drug interactions
Deutetrabenazine + Methadone
Severity: Moderate
Deutetrabenazine and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine causes somnolence and depression and adds to opioid CNS effects. It has a small QT effect at usual doses, which may add to methadone-related QT prolongation in susceptible patients.
What this interaction means in plain words
Deutetrabenazine and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Methadone belongs to Musculoskeletal.
Why it happens
Additive CNS depression and modest additive QT prolongation.
What to do
Monitor sedation and mood, and obtain an ECG in patients with QT risk factors or on high methadone doses. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Methadone?
MediHelp rates the interaction as moderate. Deutetrabenazine and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine causes somnolence and depression and adds to opioid CNS effects. It has a small QT effect at usual doses, which may add to methadone-related QT prolongation in susceptible patients.
How serious is the interaction between Deutetrabenazine and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and mood, and obtain an ECG in patients with QT risk factors or on high methadone doses. Correct potassium and magnesium abnormalities.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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