Drug interactions
Deutetrabenazine + Nilotinib
Severity: Moderate
Deutetrabenazine and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib prolongs the QT interval, and deutetrabenazine can have small QT effects, especially when exposure is raised. Together they increase the potential for torsades de pointes, particularly with electrolyte disturbance or bradycardia.
What this interaction means in plain words
Deutetrabenazine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain an ECG at baseline and during therapy, and correct potassium and magnesium. Avoid in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Nilotinib?
MediHelp rates the interaction as moderate. Deutetrabenazine and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib prolongs the QT interval, and deutetrabenazine can have small QT effects, especially when exposure is raised. Together they increase the potential for torsades de pointes, particularly with electrolyte disturbance or bradycardia.
How serious is the interaction between Deutetrabenazine and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and during therapy, and correct potassium and magnesium. Avoid in congenital long QT syndrome.
What other medicines interact with Nilotinib?
MediHelp also lists interactions of Nilotinib with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Nilotinib page.
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