Drug interactions
Deutetrabenazine + Nortriptyline
Severity: Moderate
Deutetrabenazine and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and have effects on cardiac repolarization. Deutetrabenazine has only a small QT effect at recommended doses, but the risk rises with other QT-prolonging drugs and electrolyte disturbances. Nortriptyline is also a CYP2D6 substrate, and deutetrabenazine metabolites are CYP2D6 substrates.
What this interaction means in plain words
Deutetrabenazine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive CNS depression and additive QT prolongation.
What to do
Monitor sedation and consider an ECG in patients with additional QT risk factors. Correct potassium and magnesium before and during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Nortriptyline?
MediHelp rates the interaction as moderate. Deutetrabenazine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and have effects on cardiac repolarization. Deutetrabenazine has only a small QT effect at recommended doses, but the risk rises with other QT-prolonging drugs and electrolyte disturbances. Nortriptyline is also a CYP2D6 substrate, and deutetrabenazine metabolites are CYP2D6 substrates.
How serious is the interaction between Deutetrabenazine and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and consider an ECG in patients with additional QT risk factors. Correct potassium and magnesium before and during therapy.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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