Drug interactions
Deutetrabenazine + Ofloxacin
Severity: Moderate
Deutetrabenazine and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofloxacin can prolong the QT interval, and deutetrabenazine may add modestly to this effect, particularly at higher exposures. Risk of torsades de pointes rises with bradycardia, electrolyte disturbances or congenital long QT.
What this interaction means in plain words
Deutetrabenazine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Correct potassium and magnesium before starting, and obtain a baseline ECG in patients with additional risk factors. Avoid the combination in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Ofloxacin?
MediHelp rates the interaction as moderate. Deutetrabenazine and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofloxacin can prolong the QT interval, and deutetrabenazine may add modestly to this effect, particularly at higher exposures. Risk of torsades de pointes rises with bradycardia, electrolyte disturbances or congenital long QT.
How serious is the interaction between Deutetrabenazine and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before starting, and obtain a baseline ECG in patients with additional risk factors. Avoid the combination in congenital long QT syndrome.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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