Drug interactions
Deutetrabenazine + Paroxetine
Severity: Moderate
Deutetrabenazine and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. This can increase dose-related adverse effects such as sedation, depression, akathisia, parkinsonism and QT prolongation.
What this interaction means in plain words
Deutetrabenazine and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated metabolism of the active dihydro-metabolites of deutetrabenazine, with possible additive QT effects.
What to do
Limit deutetrabenazine to the labeled maximum for use with strong CYP2D6 inhibitors (no more than 36 mg/day, single doses up to 18 mg). Monitor for adverse effects, mood changes and QTc in patients with additional risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Paroxetine?
MediHelp rates the interaction as moderate. Deutetrabenazine and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine is a strong CYP2D6 inhibitor and markedly raises exposure to the active metabolites of deutetrabenazine. This can increase dose-related adverse effects such as sedation, depression, akathisia, parkinsonism and QT prolongation.
How serious is the interaction between Deutetrabenazine and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit deutetrabenazine to the labeled maximum for use with strong CYP2D6 inhibitors (no more than 36 mg/day, single doses up to 18 mg). Monitor for adverse effects, mood changes and QTc in patients with additional risk factors.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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