Drug interactions
Deutetrabenazine + Pimavanserin
Severity: Moderate
Deutetrabenazine and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and parkinsonism, and deutetrabenazine may cause modest QT prolongation. Concurrent use may increase the risk of extrapyramidal symptoms, sedation, and rarely neuroleptic malignant syndrome.
What this interaction means in plain words
Deutetrabenazine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive antidopaminergic effects via VMAT2 inhibition and antipsychotic activity, with additive CNS depression and QT effects.
What to do
Monitor for parkinsonism, akathisia, sedation, and signs of neuroleptic malignant syndrome. Consider an ECG if other QT-prolonging drugs or risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Pimavanserin?
MediHelp rates the interaction as moderate. Deutetrabenazine and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause sedation and parkinsonism, and deutetrabenazine may cause modest QT prolongation. Concurrent use may increase the risk of extrapyramidal symptoms, sedation, and rarely neuroleptic malignant syndrome.
How serious is the interaction between Deutetrabenazine and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for parkinsonism, akathisia, sedation, and signs of neuroleptic malignant syndrome. Consider an ECG if other QT-prolonging drugs or risk factors are present.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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